The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) through its Division of Kidney, Urologic and Hematologic Diseases (DKUHD) invites experienced and new investigators to submit research grant applications to pursue basic and applied investigations in order to better understand the etiology and pathogenesis of Polycystic Kidney Disease (PKD), in both its autosomal dominant and autosomal recessive forms.The intent of this funding opportunity is to intensify investigator-initiated research, to attract new investigators to the field, and to increase interdisciplinary research. The ultimate aim is to facilitate PKD-related research studies, which will provide the basis for new therapeutic approaches.